Dab tsi yog hydroxychanloroquine siv rau feem ntau?

HydroxyChloroquine (HCQ)Puas yog cov tshuaj uas tau siv dav siv ntau caum xyoo los kho ntau yam mob. Ameslikas tsim los ua tshuaj tiv thaiv tshuaj tiv thaiv, nws muaj txij li tau txais qhov tseem ceeb hauv kev tswj cov kab mob autoimmune thiab lwm yam kev noj qab haus huv. Nyob rau hauv xyoo tsis ntev los no, Hydroxychanloroquine kuj tau ib lub ncauj lus ntawm kev sib cav vim nws muaj peev xwm siv los ntawm kev kho kis kab mob.

HydroxyChloroquine sulfate yog tshuaj tiv thaiv yeeb tshuaj, uas kuj muaj anti {{o {o, immunomodatory thiab anticoagulators teebmeem. Ntawm tam sim no, HydroxyChloroquine tsuas yog siv nyob rau hauv kev kho mob pob txaws ntawm kev mob caj dab, tsis muaj kev sib luag yog qeeb, thiab nws feem ntau yuav siv sijhawm li 4 hlis.

Cov nyhuv tiv thaiv antimalarial
Inhibit lub metabolism ntawm plasmodium

Concentrated nyob rau hauv Lysosomes ntawm Malaria Parasite, nws tsa lub pH tus nqi, thaiv cov kev ua si ntawm heme polymerfulations → tsub zuj zuj ntawm toxic heme → kev tuag ntawm tus cab.
Ua tau zoo nkaus xwb rau cov leeg rhiab:
Nws yog qhov ua tau zoo tiv thaiv chloroquine - rwb plasmodium (xws li Vivax Heev (essective tawm tsam yeeb tshuaj {1} awnive malaria.

Kev tiv thaiv kab mob (tseem ceeb)

Inhibit tus xov tooj {{0} zoo li receptor (tlr) signaling

Thaiv TLR7 / 9 kev ua kom muaj zog thiab txo cov tso tawm ntawm cov khoom tso tawm xws li i6 2}}} (qhov kev immunol, 2005).
Nyob ruaj Lysosomal Membrane
Txo cov kev ua tau zoo ntawm antigen kev nthuav qhia thiab inhibit ua kom tus kheej - reasse t hlwb.
Cuam tshuam nrog cov cim calcium
Inhibit qhov kev qhia ntawm CD154 ntawm t cells thiab thaiv kev ua haujlwm ntawm B Cell.

Hydroxychanloroquine sulfate (HCQ)yog tshuaj tiv thaiv kev tshuaj tiv thaiv kev siv tshuaj los kho cov kab mob lupus erythematosus, kab mob rheumatoid, kab mob thiab tawv nqaij. Nws tseem yog ib qho inhibitor ntawm autibitor ntawm autophagy thiab tus xov tooj- zoo li receptor (TLR) 7/9.

Tus Kab Mob auroimmune

Systemic lupus erythematosus (rab tes): Tswj cov tawv nqaij thiab cov khoom lag luam rau cov kab mob kis mob (sledai qhab nia).

Rheumatoid mob caj dab (RA): Relieves sib koom ua ke o thiab mob, thiab qeeb pob txha kev puas tsuaj (ua ke nrog methotrexate).
Sjogren's syndrome: txhim kho cov tsos mob ntawm lub qhov ncauj thiab qhuav qhuav.

Kev Tiv Thaiv: Pib noj nws 1 {- 2 lis piam ua ntej nkag mus rau hauv Malaria cov haujlwm (400mg tauj ib lim tiam rau cov neeg laus).

Kev Kho Mob: Nws yog qhov tsim nyog los ua ke nrog lwm cov tshuaj tiv thaiv (xws li chloroquine phosphate), thiab tshuaj tsis kam tshwm sim thaum siv ib qho tshuaj.

Noj thaum noj mov: txo cov plab hnyuv.

Lub Siab / Daim Siab tsis txaus: Dosage Haum yog qhov yuav tsum tau ua (contraindicated thaum egfr <30ml / min).
Kev tiv thaiv cov tshuaj rau Pediatric: rau Malaria kev tiv thaiv nkaus xwb (6.5mg / kg ib lim tiam, tsis tshaj 400mg).

1.Ta Muag

Kev Pab Cuam Tshuam Rov Ua Tau Zoo Dua

2. Txhob txwm

Customized Labelsand pob Compoem / ODM kev pabcuam

3.storage chav

Tebchaws USA Warehouse

4.PRE

Tus Saib Xyuas Nqe

Cov txheej txheem sib txawv sib txawv raws li tus mob:

Rau malaria: cuam tshuam cab cov metabolism.

Rau kev kab mob autoimmune: suppresses kev tiv thaiv kab mob tsis sib xws los ntawm kev cuam tshuam nrog cytokine ntau lawm thiab tsis muaj zog ntawm cell kev taw qhia.

Thaum feem ntau nyab xeeb thaum siv kom raug,HCQYuav tsum muaj kev saib xyuas mob vim yog cov kev mob tshwm sim:

Kev phiv los tshwm sim: xeev siab, mob taub hau, kiv taub hau, pob khaus.

Cov kev pheej hmoo hnyav:

Qhov muag puas (Retinopathy): ntev - siv tau yuav tsum muaj qhov kuaj qhov muag tsis tu ncua.

Lub plawv mob: tuaj yeem ua qt tev (lub plawv dhia plawv).

Hypoglycemia: tej zaum yuav txo cov ntshav qab zib hauv ntshav, tshwj xeeb yog cov mob ntshav qab zib.

HydroxychanloroquineTseem tshuav cov tshuaj muaj txiaj ntsig zoo rau Malaria, rheumatoid mob caj dab, thiab lupus. Thaum nws tau txais kev mloog thaum lub sijhawm ntawm covid-19 thoob ntiaj teb, nws siv rau tus kab mob kis tau tsis muaj pov thawj los ntawm cov pov thawj muaj zog. Cov neeg mob siv HCQ yuav tsum ua kom saib xyuas kev kho mob los saib xyuas cov peev xwm tshwm sim.

Yog tias koj tau sau cov tshuaj hydroxychanporoquine, ib txwm ua raws koj tus kws kho mob cov lus qhia thiab qhia txog ib qho tsos txawv tshwm sim sai. Rau cov neeg xav tias nws rau tawm - Daim ntawv lo rau siv, sab laj nrog cov kev pheej hmoo mob thiab cov txiaj ntsig zoo.

Koj puas xav paub cov ntsiab lus ntxiv ntawm ib qho twg ntawm hydroxychanloroquine? Qhia rau peb paub hauv cov lus!

Alarcón, GS, li Al. (2007). HydroxyChloroquine siv kwv yees kev ua kwv daws hauv cov neeg mob lupus. Mob caj dab & rheumatism, 56 (3), 876-881.

Kuhn, A., li al. (2016). HydroxyChloroquine hauv dermatology: kev siv tshuab thiab tshuaj kho mob. Phau ntawv Journal of American Academy of Dermatology, 74 (2), 321-344.

Raoult, D., li al. (1999). Kev kho mob q ua npaws nrog hydroxychanlinequine thiab doxycycline. Cov tshuaj tiv thaiv kab mob antimicrobial thiab tshuaj siv tshuaj, 43 (4), 774-778.