| Khoom npe | Galantamine Hydrobromide |
| Molecular Luj | 368.27 g / mol |
| UNII Code | MJ4PTD2VVW |
| Qhov tshwm sim | Dawb rau yuav luag dawb hmoov |
| Purity | 99% los ntawm HPLC |
| CAS Nr | 1953-04-4 |
| Cov mis mos molecular | C₁₇H₂₁NO₃ • HBr |
| Solubility | Sparingly soluble hauv dej |
| Cia | Hmoov: -20℃(ruaj khov mus txog 3 xyoos) |
Khoom Description
Dab tsi yog Galantamine Hydrobromide?
Galantamine hydrobromide yog ib qho kev thim rov qab, kev sib tw acetylcholinesterase inhibitor. Clinically, nws yog feem ntau siv los kho cov tsos mob dementia los ntawm mob me mus rau nruab nrab Alzheimer's disease (AD). Txawm li cas los xij, nws tsis kho tus kab mob, thiab kev kho mob yuav tsum pib nrog kev siv tshuaj tsawg thaum saib xyuas cov kev mob tshwm sim xws li xeev siab thiab bradycardia.
Yooj yim muab tso, nws yog ib qho tshuaj uas sim ua kom qeeb kev txawj ntse los ntawm kev tswj cov neurotransmitters hauv lub hlwb.
Xi'an Tongze muaj cov khoom zoo sib xws raws li teev hauv qab no. Thov koj xav tiv tauj peb ncaj qha kom paub meej ntxiv.
COA ntawm Galantamine Hydrobromide
Daim ntawv thovntawmGalantamine Hydrobromide
Cov ntawv thov ntawm galantamine hydrobromide poob rau hauv ob pawg loj: nws thawj thiab feem ntau siv yog nyob rau hauv kev kho mob ntawm Alzheimer's disease; Tsis tas li ntawd, hauv qee lub tebchaws thiab cheeb tsam, nws muaj lwm yam kev siv tshuaj kho mob raws li nws cov tshuaj pharmacological.
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Daim ntawv thov |
Cov lus piav qhia ntxaws |
Daim ntawv thov |
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Cov kab mob neurological thiab raug mob |
Txhim kho kev nco tsis zoo: Nws yog siv rau benign memory disorders, nrog rau cov uas tshwm sim los ntawm dementia thiab organic hlwb txhab. |
Cov kab mob neurological thiab raug mob |
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Cov kab mob Neuromuscular: Siv los kho myasthenia gravis, kev mob autoimmune uas tuaj yeem ua rau cov leeg tsis muaj zog |
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Sequelae ntawm cov hlab ntsha raug mob: Siv rau kev sib kis ntawm poliomyelitis, nrog rau kev hnov qab thiab lub cev muaj zog los ntawm cov kab mob neurological lossis kev raug mob -4. |
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Tshuaj loog thiab phais |
Antagonistic cov leeg relaxants: Lawv tau siv thaum kawg ntawm kev phais los tiv thaiv cov leeg nqaij so ntawm rotoxine chloride thiab nws cov analogues (tsis yog depolarizing nqaij relaxants), pab cov neeg mob rov ua pa thiab cov leeg ua haujlwm -4-7 |
Tshuaj loog thiab phais |
Cov txiaj ntsig ntawm Galantamine Hydrobromide
Qhov txiaj ntsig tseem ceeb ntawm galantamine hydrobromide yog nws siv hauv kev kho mob me me mus rau nruab nrab Alzheimer's disease (AD) ntsig txog dementia, qhov uas nws tuaj yeem txhim kho cov neeg mob kev paub txog kev ua haujlwm, kev ua ub no ntawm kev ua neej nyob txhua hnub, thiab kev ua haujlwm tag nrho rau qee qhov.
Txhim kho cov tsos mob ntawm Alzheimer's Disease
Cov kev tshawb fawb soj ntsuam tau lees paub tias, piv rau cov placebo, galantamine muab cov txiaj ntsig tseem ceeb rau cov neeg mob hla ntau qhov tseem ceeb. Cov txiaj ntsig no tsis yog "kho," tab sis ua haujlwm kom qeeb ntawm cov tsos mob, tswj, lossis txhim kho kev ua haujlwm tam sim no thaum kho.
Dose-Response Relationship: Galantamine nthuav tawm qhov kev sib raug zoo ntawm koob tshuaj tiv thaiv, txhais tau hais tias cov koob tshuaj ntau dua tau txais txiaj ntsig zoo rau kev kho mob. Txawm li cas los xij, kev siv tshuaj ntau dua kuj tseem cuam tshuam nrog kev pheej hmoo ntawm kev phiv ntau dua (xws li xeev siab). Yog li, cov txheej txheem kho mob yuav tsum pib nrog koob tshuaj 8 mg / hnub thiab maj mam nce koob tshuaj txhua 4 lub lis piam kom ua tiav qhov zoo sib npaug ntawm kev ua tau zoo thiab kev zam.
Kev txwv tseem ceeb thiab ceeb toom (tsis yog qhia)
1. Tsis yog siv rau kev puas siab puas ntsws me me: Kev sim tshuaj ntsuam xyuas tau pom tias qhov kev tuag ntawm cov pab pawg galantamine tau ntau dua li cov placebo pawg (13 tus neeg mob vs . 1 rooj plaub) thaum kho cov neeg mob uas muaj kev puas hlwb me me; Yog li ntawd, cov tshuaj no yuav tsum tsis txhob siv los kho mob me ntsis kev puas hlwb.
2. Tsis Hloov Kab Mob Kev Loj Hlob: Cov pov thawj tam sim no qhia tau tias thaum galantamine tuaj yeem txhim kho cov tsos mob, nws tsis hloov cov txheej txheem neurodegenerative ntawm Alzheimer's disease.
3. Tsis muaj txiaj ntsig rau Cov Hom Dementia tshwj xeeb: Tsis muaj pov thawj tias nws muaj txiaj ntsig zoo hauv kev kho lwm hom dementia lossis cov tsos mob ntawm kev nco tsis zoo.
4. Rau kev tshawb fawb siv xwb: Raws li ib tug biochemical reagent, galantamine yog siv nyob rau hauv kev tshawb fawb ntawm teb xws li neuroscience thiab apoptosis, tab sis nws siv rau tib neeg kev kuaj mob los yog kev kho mob yog nruj me ntsis txwv tsis pub.
Ntim & Kev xa khoom
Khoom Description
Hu rau PAGE
1.Nrhiav txoj kev:
Email: alice@xaheshun.com
whatspp: +8618509260106
Online instant messaging
2. Hu rau cov ntaub ntawv:
Lub npe: Alice
Xov tooj: +8618509260106
Email: alice@xaheshun.com
FAQ
Q1: Cov qauv tshuaj pharmacopeia twg yog koj li Galantamine Hydrobromide API ua raws?
A: Peb Galantamine Hydrobromide API tau ua raws li qhov tseeb ntawm USP, EP, thiab BP. Peb muab Daim Ntawv Pov Thawj Kev Ntsuam Xyuas Kev Ntsuam Xyuas (COA) rau txhua pawg, kom ntseeg tau tias qhov kev ntsuam xyuas (HPLC) tsis tu ncua ntau dua lossis sib npaug li 99.0% thiab ua tau raws li tag nrho cov kev txwv rau cov khoom muaj feem xyuam thiab kev sib hloov kho qhov muag.
Q2: Lub hauv paus chiv keeb ntawm koj API yog dab tsi, thiab koj yuav tswj hwm lub ntsiab lus tsis huv?
A: Peb muab ob qho tib si [Natural Extraction / Synthetic] Galantamine HBr. Txhawm rau kom muaj kev nyab xeeb, peb nruj me ntsis ua raws li ICH Q3D cov lus qhia rau lub hauv paus impurities. Siv ICP-MS thev naus laus zis, peb lav tias cov hlau hnyav (Pb, As, Hg, Cd) tau khaws cia zoo hauv qab 10ppm, ua tau raws li qhov kev nyab xeeb siab tshaj plaws rau kev siv tshuaj.
Q3: Puas yog Particle Size Distribution (PSD) customizable rau cov ntawv tshwj xeeb?
A: To taub tias solubility cuam tshuam rau bioavailability, peb muab Micronized Galantamine Hydrobromide nrog PSD customizable. Peb cov txheej txheem micronization ua tiav d90 < 10μm lossis 20μm, uas yog qhov zoo tagnrho rau kev tsim cov ntsiav tshuaj uas tsis sib xws lossis txuas ntxiv-tso tshuaj ntsiav.
Q4: Dab tsi yog qhov yuav tsum tau khaws cia thiab cov ntaub ntawv ruaj ntseg mus sij hawm ntev?
A: Galantamine HBr ruaj khov thaum khaws cia hauv qhov chaw txias, qhuav (hauv qab 25℃lossis 2-8℃rau lub sijhawm ntev) thiab tiv thaiv lub teeb. Raws li peb cov kev tshawb fawb ICH ruaj khov, API muaj lub sijhawm rov ua dua ntawm 36 lub hlis thaum khaws cia hauv nws qhov qub, lub Hoobkas kaw cov ntawv ci txhuas thiab fiber ntau nruas.
Q5: Koj puas txhawb nqa kev kuaj thib peb thiab kuaj kev thov?
A: Peb txais tos pob tshab. Peb muab 10g-50g cov qauv rau kev kuaj xyuas los ntawm lub chaw soj nstuam ywj pheej xws li SGS, Eurofins, lossis Intertek. Tsis tas li ntawd, rau cov ntawv cog lus siab, peb pab tswj cov chaw taws teeb lossis ntawm qhov chaw GMP kev tshuaj xyuas los xyuas peb cov kev tswj xyuas zoo thiab cov chaw tsim khoom.
Cim npe nrov: Tuam Tshoj galantamine hydrobromide manufacturers, lwm tus neeg, Hoobkas
