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Khoom npe |
Coluracetam |
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Tshuaj npe |
N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxo-1-pyrrolidinyl)acetamide |
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Synonyms |
MKC-231, BCI-540 |
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Qhov tshwm sim |
Dawb los yog dawb hmoov hmoov |
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Purity |
99% los ntawm HPLC |
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CAS Nr |
135463-81-9 |
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Cov mis mos molecular |
C19H23N3O3 |
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Solubility |
Insoluble hauv dej; Soluble hauv DMSO (piv txwv li, Ntau dua lossis sib npaug ntawm 60 mg / mL); |
Khoom Description
Dab tsi yog Coluracetam?
Coluracetam (txoj cai kev loj hlob: MKC-231, Coluracetam (kev loj hlob code: MKC-231, BCI-540)) yog ib tug nootropic tus neeg sawv cev ntawm lub racetam tsev neeg. Nws yog Ameslikas tsim los ntawm Mitsubishi Tanabe Pharma nyob rau hauv Nyiv feem ntau raws li ib tug tshiab high-affinity choline uptake (HACU), lub hom phiaj ntawm kev txhim kho kev txawj ntse, tshwj xeeb tshaj yog nyob rau hauv kev lag luam choline uptake (HACU). nws tus nqi hauv kev kho mob ntawm kev paub tsis meej xws li Alzheimer's disease.
Coluracetam yog ib qho kev sim racetam compound uas tsis muaj cov tshuaj pharmacological. Nws belongs rau tiam thib ob ntawm nootropics thiab feem ntau ua rau lub siab choline uptake (HACU) system nyob rau hauv lub hlwb. Nws yog tsim los txhim kho cholinergic neurotransmission, uas tuaj yeem txhim kho kev txawj ntse xws li kev nco thiab kev kawm muaj peev xwm.
Xi'an Tongze muaj cov khoom zoo sib xws raws li teev hauv qab no. Thov koj xav tiv tauj peb ncaj qha kom paub meej ntxiv.
COA ntawmColuracetam
Daim ntawv thovntawmColuracetam
Coluracetam yog thawj zaug tsim los ntawm Mitsubishi Tanabe Pharma hauv Nyij Pooj, feem ntau yog tus neeg sib tw tshuaj rau kev kho mob Alzheimer's. Hauv kev tshawb fawb tom qab, nws cov ntawv thov muaj peev xwm tau tshawb nrhiav ntxiv, suav nrog ntau qhov chaw suav nrog cov kab mob neuropsychiatric thiab kab mob ophthalmic. Cov hauv qab no muab cov lus piav qhia ntxaws txog nws cov ntawv thov tshwj xeeb.
|
Qhov chaw thov |
Kev tshawb fawb theem |
Cov koom haum tshawb fawb tseem ceeb |
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Mob Alzheimer |
Phase II kev soj ntsuam kev sim (tawm) |
Mitsubishi Tanabe Pharmaceutical |
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Kev nyuaj siab / ntxhov siab vim |
Phase IIa kev soj ntsuam kuaj (Tiav) |
BrainCells Inc. |
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Schizophrenia |
Preclinical (tsiaj sim) |
Kev tshawb fawb |
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Retinopathy / optic paj raug mob |
kev tshawb nrhiav thaum ntxov |
Kev tshawb fawb |
Cov txiaj ntsig ntawm Coluracetam
| Cov txiaj ntsig tshwj xeeb | Kev sim qauv | Cov ntaub ntawv tshawb fawb |
| Txhim kho kev kawm spatial thiab nco | Inducing nco tsis txaus hauv nas siv cov neurotoxin AF64A | Kev tswj hwm qhov ncauj ntawm 1–10 mg / kg ntawm coluracetam tau txhim kho kev kawm tsis txaus hauv cov nas hauv Morris dej tshawb nrhiav, nrog kev ua tau zoo dua piv rau cov tshuaj tacrine. |
| Txhim kho kev ua haujlwm nco | Cov nas kho nrog AF64A (T-maze test) | Tom qab 11 hnub ntawm kev tswj hwm mob ntev (0.3, 1.0, 3.0 mg / kg), cov lus teb raug rau cov nas tau nce ntau ntawm 61.1% (cov pab pawg tsis txaus) mus rau 86.1%, 85.0%, thiab 83.3%. |
| Reversing qhov poob ntawm acetylcholine (ACh) qib | nas hippocampal cov ntaub so ntswg uas AF64A induces ib tug txo nyob rau hauv AC qib | Tom qab 12 hnub ntawm kev tswj hwm mob ntev, pawg koob tshuaj 0.3 mg / kg tau rov qab ACh qib ntawm 60.8% ntawm ib txwm mus rau 84.4%; pawg koob tshuaj 1.0 mg / kg rov qab mus rau 75.5%, qhia tau tias muaj txiaj ntsig zoo. |
Ntim & Kev xa khoom
Cov lus teb rau cov neeg siv khoom
Hu rau PAGE
1.Nrhiav txoj kev:
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2. Hu rau cov ntaub ntawv:
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Email: alice@xaheshun.com
FAQ
Q1: Tus qauv purity ntawm koj Coluracetam API yog dab tsi, thiab koj yuav ua li cas kom ntseeg tau cov khoom sib xws?
A: Peb Coluracetam API tswj qhov purity ntau dua lossis sib npaug li 99.0% (validated los ntawm HPLC). Txhua batch tau txais kev tswj xyuas zoo, suav nrog NMR rau kev txheeb xyuas cov qauv thiab GC rau kev txheeb xyuas cov kuab tshuaj seem. Peb muab Batch-Specific Certificate of Analysis (COA) kom paub meej tias txhua qhov kev xa khoom tuaj yeem ua tau raws li cov khoom siv tshuaj lom neeg uas yuav tsum tau ua kom ruaj khov.
Q2: Dab tsi yog cov yam ntxwv solubility thiab cov qauv txheej txheem rau Coluracetam?
A: Coluracetam yog cov roj-soluble Racetam derivative nrog dej solubility tsawg. Nws yog soluble heev hauv cov kuab tshuaj organic xws li DMSO (Ntau dua lossis sib npaug ntawm 60 mg / mL), Ethanol, thiab PEG400. Rau aqueous-raws li formulations, kev siv cov surfactants zoo li Tween 80 los yog co-solvents yog pom zoo kom muaj ib tug homogeneous tov.
Q3: Dab tsi yog qhov pom zoo khaws cia kom tswj tau Coluracetam lub txee lub neej?
A: Coluracetam API yog rhiab rau lub teeb thiab noo noo. Nws yuav tsum tau muab cia rau hauv qhov chaw txias, qhuav (2-8℃lossis qis dua 25 degree), deb ntawm tshav ntuj ncaj qha thiab cua sov. Thaum khaws cia rau hauv nws qhov qub, lub Hoobkas kaw lub tshuab nqus tsev-packed aluminium foil hnab, cov khoom muaj lub txee ruaj khov ntawm 24 txog 36 lub hlis.
Q4: Koj puas tuaj yeem muab cov qauv rau kev kuaj xyuas thib peb (SGS / Eurofins)?
A: Yog lawm. Peb txhawb kev pob tshab thiab txhawb nqa qhov kev sim thib peb. Peb tuaj yeem muab 10g-50g cov qauv sim rau koj qhov kev lees paub sab hauv lossis xa khoom mus rau cov chaw sim ywj pheej xws li SGS, Eurofins, lossis Colmar. Qhov no ua kom API sib phim koj cov peev txheej tshwj xeeb thiab kev nyab xeeb ua ntej kev yuav khoom ntau.
Q5: Dab tsi yog koj txoj cai shipping rau 2026 thoob ntiaj teb logistics thiab kev lis kev cai?
A: Peb siv cov chaw xa khoom tshwj xeeb (DHL / FedEx / TNT) thiab muab kev pabcuam DDP (Delivered Duty Them) rau cov cheeb tsam tshwj xeeb kom txo qis kev lis kev cai qeeb. Tag nrho cov khoom xa tuaj API tau ntim rau hauv ob txheej txheej PE hnab hauv UN-rated fiber nruas lossis tamper-pob tshab txhuas lub hnab, nrog rau tag nrho cov ntawv tshaj tawm tsim nyog los xyuas kom meej 100% kev xa khoom tiav.
Cim npe nrov: coluracetam api, Tuam Tshoj coluracetam api manufacturers, lwm tus neeg, Hoobkas
