Lub Xesofensine ua tau haujlwm tiag?

Sivofensineyog tus tshiab triple monoamine ruptor (Sndri) uas cuam tshuam rau lub qab los noj mov thiab metabolism los ntawm kev tswj hwm qib neurotriesmitter. Tesofencin yog xub pib tsim los ntawm Danish lub tuam txhab neurosearch thiab tau raug tso cai rau lwm cov tuam txhab kom paub tshawb fawb ntxiv thiab kev tshawb fawb.

Nws cov tshuaj lom neeg lub npe yog (1R) - 1- {3-pyrylpropin-1 -} Nws yog soluble hauv cov kuab tshuaj organic (xws li DMOPS, ethanol), thiab muaj cov kua txiv tsis zoo. Vim tias nws yog qhov txaus ntshai thiab oxidation, nws yuav tsum tau ceev cia kom deb ntawm lub teeb, ntim thiab khaws cia ntawm 2-8℃kom tiv thaiv kev tsis txhob muaj kev tsis pom zoo. Hauv qhov no, Xi'an Tongze Bio tuaj yeem muab ntim rau vial thiab txhuas ntawv ci hnab.

1. Kev kho mob ntawm kev rog

TtxheebUa haujlwm los ntawm triple monoamine rauv taws (Sndri) thiab yog tsuas yog rau triple neurotransmitter, suav nrog dopamine (da), norpinephrine (thiab serotonin (5-ht).

1) Suppress Noj Qab Haus

Txog 5-HT (Serotonin) Kev nce qib, pomc neurons hauv hypothalamus tau qhib kom ua tiav, yog li kev txhawb nqa cov nyhuv ntawm satiety

Tom qab ntawd nce ntxiv los ntawm da (dopamine), uas txo qhov "nqhis" rau cov piam thaj ntau thiab cov khoom noj muaj rog siab

2) Txhawb nqa rog rog

Los ntawm kev nce ntawm ne (norsepinephrine), 3-adrenaline recetors tau ua kom tiav, yog li txhawb kev yoo ntshav cov ntshav thiab cov tawv nqaij, thiab txhim kho cov pob zeb metabolic.

Haum rau cov neeg mob uas muaj kev rog nrog BMI ntau dua lossis muaj sib npaug nrog tus mob bmi ntau dua lossis cov neeg mob metabolic (bypertension, hom 2 ntshav qab zib, dyslipidemia). Nws raug nquahu kom ua qhov ncauj tsiav tshuaj ntawm cov khoom lag luam uas muaj feem xyuam. Qhov ntau npaum li cas yog pib qhov pib: 0.25 mg / hnub, thiab maj mam kho nws mus rau 0.5 mg-1 mg / hnub raws li kws kho mob cov lus qhia. Feem ntau nws yuav siv sijhawm li 3-6 lub hlis kom ua tiav qhov hnyav poob phaus.

2. Tshawb nrhiav ntawm cov kab mob neurological

Rau Alzheimer's / Parkinson cov kev tshawb fawb mob, nws txhim kho kev ua haujlwm thiab kev ua tiav los ntawm kev nce dopamine thiab norepinephrine ntau ntau. Vim cov kev mob tshwm sim uas tshwm sim thaum lub sijhawm poob phaus, peb tau ua cov kev tshawb fawb tob txog qhov no.

Cov ntawv tau lees txais ntawmTtxheeb suav nrog hmoov thiab tsiav tshuaj. Nyob rau tib lub sijhawm, Xi'an Tersion biological tuaj yeem muab cov kev pabcuam ntawm cov khoom siv, los ntawm cov ntsiav tshuaj ua haujlwm, thiab tom qab ntawd cov kab txuas ntxiv thiab tuaj yeem muab ib qho kev pabcuam tsis tu ncua thiab tuaj yeem muab ib qho kev pab cuam tsis tu ncua.

1. Cov kev mob tshwm sim ib qho ntxiv, muaj feem xyuam rau kev ua haujlwm ntawm txoj kev mob siab rau lub qhov ncauj, cov tsos mob tsis tsaug zog, thiab lub plawv dhia ceev ceev. Nws kuj tseem muaj kev cuam tshuam rau lub plab zom mov, thiab nws yuav ua rau quav ntsej thiab xeev siab.

2. Cov tshuaj tiv thaiv loj heev

Ntawm kev cuam tshuam ntawm cov hlab plawv, kev kub siab hlav kub thiab arrhythmia yuav tshwm sim.

Rau cov teebmeem neurological, tshwj xeeb tshaj yog thaum ua ke nrog SSRI / SNRI tshuaj tiv thaiv kev ntxhov siab, kub taub hau, myoclonus, thiab tsis meej pem yuav tshwm sim.

3. Cov Pab Pawg Tshwj Xeeb

Nrog rau cov neeg mob nrog cov kab mob plawv, mob hlwb, cov poj niam cev xeeb tub thiab cov poj niam cev xeeb tub thiab kev pub niam mis. Tshwj xeeb tshaj yog rau cov neeg mob nrog cov kab mob plawv, nojTtxheeb{-} Cov khoom lag luam uas cuam tshuam dab tsi yuav ua rau keeb kwm ntawm myocardial ntawm myocardial infarction / stroke thiab muaj kev pheej hmoo siab ntawm tsis tswj kev kub siab.

TtxheebYog zoo dua li cov tshuaj uas twb muaj lawm, thiab lwm yam, thiab xav tau nruj me ntsis ua raws li cov tshuaj no. Nws yuav tsum tau coj mus ntev thiab qhov poob phaus yuav tsum yog qhov tseem ceeb tsis pub dhau 6 lub hlis. Yog li ntawd, rau cov neeg rog rog,TtxheebMuaj txiaj ntsig zoo nyob rau hauv luv - sij hawm (tsis pub dhau 6 lub hlis) poob phaus thiab cov kev cai metabolic.

1.Lub Tesofensine, ib qho tshiab triple monoamine ruptorety, induces}}}}}}} AdrenoCeptor thiab dopamine D1 receptor pathwing hauv cov khoom noj-ua rau nase

2.Tesofensine induces pub qab los noj mov tshiab thiab poob phaus los ntawm kev cuam tshuam ntawm serotonin, noradrenaline thiab DOPAMINE RUKUAKE

3.Kev tsis sib haum xeeb nyob rau hauv lub cardiometabolic pheej hmoo cuam tshuam nrog anti - Kev rog rog

Phau ntawv Journal: Cov ntaub ntawv Atherosclerosis tam sim no

4.QhiaBhotherapyRau kev rog: tshuaj tshiab thiab tawm cov hom phiaj
Phau Ntawv Journal: CIrculation kev tshawb nrhiav