Hauv kev kho pob txha, cov tshuaj peptide hu ua Abaloparatide yog ntsiag to revolutionizing kev kho mob. Raws li kev kho tshiab tau txais kev saib xyuas ntawm cov neeg mob osteoporosis thiab cov kws kho mob, nws cog lus tias yuav txhim kho cov pob txha loj dua li cov tshuaj bisphosphonate. Tab sis txoj kev kho no puas zoo dua rau cov kev xaiv uas twb muaj lawm? Wb delve rau hauv lub ntsiab lus kub no.
Abaloparatide yog dab tsi?
Abaloparatideyog ib qho hluavtaws peptide homologous rau tib neeg parathyroid hormone-related protein (PTHrP). Nws txhawb kev tsim cov pob txha los ntawm kev xaiv ua kom cov parathyroid hormone type 1 receptor (PTH1R) signaling pathway.
Tsis zoo li cov tshuaj tiv thaiv ib txwm muaj -resorptive therapies, Abaloparatide belongs rau qeb ntawm "cov pob txha tsim tawm":
1.Txoj kev txhawb nqa osteoblast kev ua haujlwm los txhawb kev tsim cov pob txha tshiab
2.Increases pob txha ceev nyob rau hauv ob qho tib si trabecular thiab cortical pob txha
3.Nws cov txheej txheem tshwj xeeb ntawm kev txiav txim txo qhov kev pheej hmoo ntawm hypercalcemia
Lub US FDA tau pom zoo nws hauv 2017 rau kev kho pob txha pob txha uas muaj kev pheej hmoo ntawm pob txha hauv cov poj niam postmenopausal, ua rau muaj kev hloov pauv tseem ceeb hauv cov tswv yim kho mob osteoporosis.
Sib piv kev soj ntsuam nrog cov kev kho mob
1. Kev sib piv nrog Teriparatide
Hauv kev sim tshuaj ACTIVE, abaloparatide tau nce cov pob txha pob txha pob txha pob txha los ntawm 12.8% dhau 18 lub hlis, piv rau 9.6% rau teriparatide. Qhov tshwj xeeb tshaj yog, pab pawg abaloparatide tau qhia txog kev txo qis ntawm 86% ntawm kev pheej hmoo ntawm cov pob txha pob txha tshiab, uas qhia qhov zoo tshaj plaws ntawm teriparatide.
2. Kev sib piv nrog cov tshuaj Bisphosphonate
Bisphosphonates xws li alendronate feem ntau qeeb pob txha los ntawm inhibiting osteoclasts, whereas abaloparatide nquag txhawb cov pob txha tsim. Rau cov neeg mob uas muaj pob txha loj lossis ntau pob txha, qhov "tsim" txoj hauv kev no yuav muaj kev tiv thaiv ntau dua.
3. Ntsuas qhov tshwm sim tiag tiag thiab qhov txaus ntshai
Txawm hais tias abaloparatide qhia tau hais tias cov pob txha ntom ntom ntom ntom ntom ntom ntom ntom ntom ntom ntom ntom ntom ntom ntom ntom ntom ntom ntom, cov neeg mob xav tau kev txhaj tshuaj txhua hnub, thiab lub sijhawm kho feem ntau txwv rau ob xyoos. Hauv qhov sib piv, qhov ncauj bisphosphonates muab kev yooj yim dua thiab ntev dua - cov ntaub ntawv kev nyab xeeb.
| Tshuaj (Sawv cev) | Qeb | Lub luag haujlwm tseem ceeb | Hoob kho kev txwv | Yam ntxwv |
| Abaloparatide | Cov pob txha tsim txhawb nqa | Kev xaiv ua kom PTH1R, muaj zog pob txha tsim | 24 hli | Qhov tseem ceeb txo txoj kev pheej hmoo ntawm pob txha pob txha nrog qis kev pheej hmoo ntawm hypercalcemia. |
| Teriparatide | Cov pob txha tsim txhawb nqa | Ua kom sib npaug ntawm PTH1R ua rau cov pob txha tsim | 24 hli | Thawj cov pob txha- tsim tshuaj, nrog cov pov thawj ua tau zoo tab sis muaj kev pheej hmoo siab me ntsis ntawm hypercalcemia. |
| Romosozumab | Cov pob txha tsim txhawb nqa | Inhibits osteosclerotic proteins, nrog bidirectional kev tswj (thawj txhawb cov pob txha tsim, ces inhibiting resorption) | 12 hli | Ua tau zoo heev hauv ib xyoos, tab sis muaj kev ceeb toom txog kev pheej hmoo mob plawv. |
| Bisphosphonates | Anti- pob txha resorption tus neeg sawv cev | Inhibit osteoclasts kom qeeb pob txha | Feem ntau yuav tsum tau ntsuas txhua 3 mus rau 5 xyoos. | Muab qhov ncauj los yog tso rau hauv cov hlab ntsha ua thawj zaug - cov tshuaj yooj yim. Kev siv sijhawm ntev - yuav tsum tau saib xyuas qhov tsis tshua muaj tshwm sim. |
| Denosumab | Anti- pob txha resorption tus neeg sawv cev | Inhibits RANKL, haib suppresses pob txha resorption | Ntev -lub sij hawm (yuav tsum tau txhaj tshuaj txhua 6 lub hlis) | Muaj txiaj ntsig zoo, tab sis kev txiav tawm ua rau cov pob txha rov qab hnyav heev, xav tau kev kho txuas ntxiv. |
Leej twg yog nws haum rau thiab ceev faj (hauv kev kho mob)
1. Cov lus qhia:
Cov poj niam postmenopausal nrog keeb kwm ntawm osteoporotic pob txha
Cov neeg mob muaj kev pheej hmoo siab rau ntau pob txha
Cov neeg uas tsis txaus siab los yog intolerance rau cov pa kev kho mob
2. Lub Sij Hawm Kev Kho Mob thiab Ua raws li - Kev Tswj Xyuas:
Kev kho Abaloparatide feem ntau txwv rau 24 lub hlis, ua raws li kev hloov pauv mus rau kev kho tshuaj tiv thaiv -resorptive (xws li, bisphosphonates los yog denosumab) kom tswj cov pob txha ceev. Lub tswv yim "kev kho raws li niaj zaus" no sawv cev rau qhov ua tau zoo tshaj plaws ntev - txoj hauv kev tswj xyuas tam sim no.
3. Kev nyab xeeb thiab kev saib xyuas:
Cov kev mob tshwm sim muaj xws li qhov chaw txhaj tshuaj, kiv taub hau, thiab palpitations. Raws li nrog tag nrho cov kev kho mob osteoporosis, kev saib xyuas tsis tu ncua ntawm cov pob txha ceev thiab lub raum ua haujlwm yog ib qho tseem ceeb ntawm cov khoom.
Lub luag haujlwm ntawm Abaloparatide hauv Kev Tswj Osteoporosis
Raws li ntau tiag tiag- cov ntaub ntawv ntiaj teb sib sau ua ke, abaloparatide tuaj yeem ua lub luag haujlwm ntau dua hauv cov hauv qab no:
1.Raws li kev kho mob anabolic nyiam rau cov neeg mob osteoporosis hnyav
2. Muaj peev xwm ua ke siv nrog cov tshuaj tiv thaiv tshiab -resorptive agents
3.Txoj kev kho tus kheej rau cov neeg mob hauv cov pab pawg neeg tshwj xeeb
Xaus
Abaloparatide sawv cev rau kev nce qib tseem ceeb hauv kev kho mob pob txha, muab cov kev xaiv tshiab muaj zog rau cov neeg mob siab -. While data suggest it may outperform certain traditional therapies in increasing bone density and reducing fracture risk, the "best" treatment remains individualized.
Rau cov neeg mob, nkag siab txog txhua yam kev xaiv muaj, koom nrog kev sib tham qhib nrog cov kws kho mob, thiab txiav txim siab txog qhov cuam tshuam ntawm kev kho mob-xws li kev ua neej, nqi, thiab tus nqi ntawm tus kheej- yog qhov tseem ceeb rau kev txiav txim siab.
Raws li kev tshawb fawb txuas ntxiv mus, peb cia siab tias yuav muaj cov ntaub ntawv ntxiv ntawm abaloparatide lub sijhawm ntev - cov txiaj ntsig thiab cov tswv yim zoo siv los piav qhia qhov kev cog lus no qhov chaw nyob hauv thaj chaw tswj kev mob pob txha.
Tsis lees paub
Cov ntsiab lus no yog muab rau kev kawm thiab cov ntaub ntawv xov xwm nkaus xwb thiab tsis yog cov kws tshaj lij cov lus qhia, kev kuaj mob, lossis kev kho mob. Nco ntsoov sab laj nrog koj tus kws kho mob thawj zaug lossis lwm tus kws kho mob uas tsim nyog ua ntej pib, hloov pauv, lossis nres kev kho mob.
Kev siv
1.FDA pom zoo kev kho mob tshiab rau osteoporosis hauv cov poj niam postmenopausal uas muaj kev pheej hmoo ntawm pob txha
2. "ACTIVE: Ib qho Randomized, Ob npaug-Qhov muag tsis pom kev, Placebo-Tshuaj, Theem 3 Kev sim ntawm Abaloparatide hauv Cov Poj Niam Postmenopausal nrog Osteoporosis" JAMA Network - ACTIVE Trial
3 "Ib qho Randomized, Ob npaug-Dis muag, Placebo-Tshuaj Kev Kawm ntawm Abaloparatide hauv Cov Poj Niam Tom Qab Menopausal Osteoporosis: Cov txiaj ntsig los ntawm ACTIVExtend Trial" Lub Lancet - ACTIVExtend Trial
4.ASBMR Patient Resources - Osteoporosis
5.International Osteoporosis Foundation - Kev Kho Mob