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Khoom npe |
Bremelanotide Acetate |
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Synonyms |
PT141; PT-141 (BREMELANOTIDE); MTPT-141; Bremerdam; REMELANOTIDE; Brmelanotice; BREMELANOTIDE; Peptide PT-141; PT-141 |
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Qhov tshwm sim |
Dawb los yog daj daj hmoov hmoov |
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Specification |
99% los ntawm HPLC |
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CAS Nr |
121062-08-6 (Acetate) CAS TSIS TAU. |
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Cov mis mos molecular |
C50H68N14O10 |
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Qib |
API (USP) |
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Cia |
Tsis txhob khov ntau zaus -thaw cycles thaum lub sij hawm cia. Rau lub sijhawm ntev - khaws cia, tso rau hauv tub yees ntawm -20℃. |
Khoom Description
Bremelanotide Acetate yog dab tsi?
PT141, tseem hu ua Bremelanotide, yog ib qho hluavtaws cyclic peptide muab los ntawm cov tshuaj hormone alpha{1}}melanocyte- stimulating hormone ( -MSH). Raws li melanocortin receptor agonist, nws feem ntau tsom rau melanocortin-4 receptor (MC4R) nyob rau hauv nruab nrab paj hlwb tswj kev ua haujlwm ntawm kev sib deev. Tsis zoo li phosphodiesterase type 5 (PDE5) inhibitors, nws ua los ntawm txoj hauv kev neurochemical es tsis yog vascular mechanisms, ua rau nws muaj kev xaiv tshwj xeeb rau kev kho kev sib deev tsis zoo.
Product COA
Certificate Of Analysis
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Khoom npe |
Tom ntej: Bremelanotide PT141 |
CAS Nr. |
121062-08-6 |
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Molecular Formula |
C50H68N14O10 |
Molecular Luj |
1085.23 |
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Batch No. |
XR23110801-6 |
Hnub tim ntawm Mfg |
Peb Hlis 27, 2024 |
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Daim ntawv pov thawj |
Enterprise Standard |
Hnub tim rov kuaj dua |
Peb Hlis 26, 2027 |
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Cia |
Nyob rau hauv ib lub thawv airtight, tiv thaiv los ntawm lub teeb, ntawm qhov kub ntawm 2 mus rau 8 degree. |
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TEST |
SPECIFICATION |
TSEEM CEEB |
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Qhov tshwm sim |
Dawb los yog yuav luag dawb fluffy hmoov |
Ua raws |
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Solubility |
Soluble hauv dej |
Ua raws |
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Cov ntsiab lus dej (Karl Fischer) |
Tsawg dua lossis sib npaug li 8.0% |
2.20% |
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Sodium ion |
Tsawg dua lossis sib npaug li 5.0% |
1.65% |
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Acetic acid |
Tsawg dua lossis sib npaug rau 0. 1% |
0.07% |
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Trifluoroacetic acid |
Tsawg dua lossis sib npaug li 0.5% |
Tsis Pom |
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Peptide Purity (los ntawm HPLC) |
Ntau dua lossis sib npaug li 98.0% |
99.32% |
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Yam khoom (los ntawm HPLC) |
Tag nrho Impurities (%) Tsawg dua lossis sib npaug li 2.0% |
0.68% |
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Loj tshaj Ib Leeg Impurity (%) Tsawg dua lossis sib npaug li 1.0% |
0.31% |
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Kab mob Endotoxins |
Tsawg dua lossis sib npaug li 10EU / mg |
Ua raws |
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Assay |
Ntau dua lossis sib npaug li 90.0% |
94.42% |
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Residual Solvents |
NMT 0.041% |
0.03% |
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Xaus |
Cov khoom lag luam no ua raws li cov qauv kev lag luam thiab tsim nyog. |
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Cov txiaj ntsig ntawm Bremelanotide PT141 Peptide
1. Kev kho kev sib deev tsis zoo
Poj niam Hypoactive Sexual Desire Disorder (HSDD): Hauv kev sim tshuaj, PT141 tau pom tias muaj kev txhim kho tseem ceeb hauv kev sib deev, kev xav, thiab kev txaus siab rau cov poj niam premenopausal nrog HSDD tau txais. Kwv yees li ntawm 50-60% ntawm cov neeg mob tau tshaj tawm tias muaj kev sib deev txaus siab piv rau 30-40% hauv pawg placebo.
Txiv neej Erectile Dysfunction (ED): Ua kom muaj zog erections hauv cov txiv neej, suav nrog cov tsis teb rau PDE5 inhibitors. Cov kev tshawb fawb pom tau tias 60-70% kev vam meej hauv kev ua tiav kev sib deev, nrog kev pib sai dua (15-30 feeb) piv rau cov tshuaj noj qhov ncauj.
2. Cov Kev Cai Neurochemical
Central Nervous System Modulation: Activates MC4R nyob rau hauv lub hypothalamus thiab limbic system, ua rau tso tawm ntawm dopamine, norepinephrine, thiab oxytocin -cov neurotransmitters tseem ceeb koom nrog hauv kev sib deev thiab kev teb.
Cov teebmeem vascular: Indirectly tsub kom qhov chaw mos ntshav ntws los ntawm stimulating pelvic paj hlwb kev ua si, pab txhawb lub cev arousal yam tsis muaj vasodilation ncaj qha.
3. Cov txiaj ntsig muaj peev xwm ntxiv
Kev Tswj Kev Noj Qab Haus Huv: Cov kev tshawb fawb hauv tsev kho mob qhia tias kev ua kom MC4R tuaj yeem txo cov zaub mov noj los ntawm kev hloov kho hypothalamic kev tshaib kev nqhis, qhia tias muaj peev xwm tswj tau qhov hnyav.
Daim tawv nqaij Pigmentation: Activates melanocortin-1 receptor (MC1R) hauv melanocytes, nce melanin ntau lawm thiab muaj peev xwm muab cov teebmeem kev tiv thaiv tiv thaiv UV hluav taws xob.
Ntsiab Mechanism ntawm Bremelanotide PT141 Peptide
1. Tshuaj Kho Mob
FDA- Pom zoo siv: Txij li xyoo 2019, PT141 tau pom zoo los ntawm FDA rau kev kho cov poj niam premenopausal nrog tau txais, generalized HSDD. Nws yog siv raws li kev txhaj tshuaj subcutaneous 45-60 feeb ua ntej xav txog kev sib deev.
Tawm - Daim ntawv thov daim ntawv lo: Siv los kho cov txiv neej ED, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob psychogenic ED lossis thaum PDE5 inhibitors tsis zoo. Nws kuj tseem tau kawm txog kev sib deev tsis zoo hauv cov poj niam postmenopausal thiab cov neeg uas muaj cov kab mob neurological xws li ntau yam sclerosis.
2. Kev Tshawb Fawb thiab Kev Txhim Kho
Pharmacological tshawb fawb: Ua haujlwm raws li tus qauv sib xyaw los kawm txog melanocortin receptor biology thiab lub hauv paus neurochemical ntawm tus cwj pwm kev sib deev.
Tshuaj Discovery: Nws cov qauv muab cov qauv rau kev tsim cov tshiab melanocortin receptor agonists rau cov xwm txheej xws li kev rog, kev quav tshuaj, thiab cov kab mob neurodegenerative.
3. Cov lus qhia yav tom ntej
Qhov ncauj Formulations: Cov kws tshawb fawb tab tom txhim kho qhov ncauj bioavailable versions ntawm PT141 los txhim kho cov neeg mob ua raws li kev siv tshuaj txhaj tshuaj.
Kev sib xyaw ua ke: Tshawb nrhiav kev sib koom ua ke nrog PDE5 inhibitors rau kev kho kom zoo ntawm ED thiab kev sib xyaw nrog cov tshuaj hormones rau kev ua haujlwm ntawm kev sib deev postmenopausal.
Cov khoom kub
FAQ
Q1. Dab tsi yog qhov kev txiav txim rau cov khoom?
Teb: Thov qhia peb cov khoom tshwj xeeb thiab ntau npaum li cas koj xav tau, muab koj cov ntaub ntawv xa khoom, xaiv txoj kev them nyiaj, thiab peb yuav npaj cov khoom xa tuaj rau koj sai li sai tau tom qab them nyiaj tiav.
Q2. Koj puas muaj qhov kev txiav txim yam tsawg kawg nkaus?
Teb: Yog, peb qhov kev txiav txim yam tsawg kawg nkaus yog ib lub thawv, thiab tau kawg koj tuaj yeem tiv tauj peb yog tias koj xav tau tsawg dua.
Q3. Tus nqi ntawm cov khoom yog dab tsi?
Teb: Peb cov nqi hloov pauv nrog kev lag luam thoob ntiaj teb. Daim ntawv teev nqi tshiab yuav muab thaum koj hu rau peb.
Q4. Yuav ua li cas them nyiaj?
Teb: Peb tuaj yeem lees txais Western Union, Bitcoin, Ali baba, Daim npav rho nyiaj, Hloov txhab nyiaj thiab lwm txoj kev them nyiaj muaj.
Q5. Thaum twg koj yuav xa cov khoom?
Teb: Tom qab tau txais cov nyiaj them poob haujlwm, peb yuav npaj cov khoom xa tuaj sai li sai tau. Tus lej taug qab yuav muab rau koj hauv 3 hnub.
Q6. Koj yuav xa cov khoom li cas?
Teb: Peb muaj kev tshaj tawm kev xa tawm, muaj zog koom tes nrog DHL, UPS, USPS, FedEx, EMS, Tuam Tshoj Air Post.
q7 ua. Thaum twg peb yuav tau txais cov khoom?
Teb: Peb yuav xa los ntawm DHL / FEDEX / UPS / USPS nthuav qhia, feem ntau nws yuav siv sijhawm li 7-15 hnub kom ncav cuag koj.
Cim npe nrov: Tuam Tshoj pt141 peptides manufacturers, lwm tus neeg, Hoobkas
