| Khoom npe |
Octreotide Acetate |
| Cas No. | 79517-01-4 |
| Ib ntus | D-Phe-c(Cys-Phe-DTrp-Lys-Thr-Cys)-Thr-ol |
| Molecular Formula | C49H66N10O10S2 |
| Molar Mass | 1019.24 g / mol |
| Purity | Ntau dua lossis sib npaug li 98% |
| impurity | Tsawg dua los yog sib npaug li 0.5% |
| Cia Kub | 2-8ºC |
| Ntim Loj | 1G / Lub raj mis, 10G / Lub raj mis, 50G / Lub raj mis lossis ntawm cov neeg siv khoom xav tau. |
Khoom Description
Dab tsi yogOctreotide Acetate?
Octreotide acetate yog ibSynthetic somatostatin analogue. Nws ua raws li cov teebmeem ntawm ntuj somatostatin thiab muaj lub sijhawm ua haujlwm ntev dua thiab muaj zog dua. Nws muaj nyob rau hauv tam sim-tso tawm thiab ntev-acting formulations rau txhaj.
Octreotide yog ib qho khoom siv hluavtaws octapeptide derivative ntawm ntuj somatostatin. Nws cov tshuaj pharmacological zoo ib yam li cov tshuaj somatostatin, tab sis nws qhov kev ua tau ntev dua. Cov khoom no muaj ntau yam kev ua haujlwm ntawm lub cev, xws li inhibition, thyrotropin; inhibition ntawm gastric acid, trypsin, glucagon thiab secretion; tuaj yeem txo lub plab zom mov thiab lub zais zis tso tawm, inhibit cholecystokinin - tso tawm ntawm trypsin, txo qis pancreatic secretion, tiv thaiv ncaj qha ntawm pancreatic parenchymal cell membrane; txo cov ntshav visceral, txo cov ntshav siab, txo cov plab hnyuv ntau dhau, ua kom plab hnyuv nqus dej thiab sodium.
Product COA
Certificate Of Analysis
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Khoom npe |
Octreotide Acetate |
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Tshuaj Formula |
C49H66N10O10S2 |
Molecular Luj |
1019.24 | |
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CAS |
83150-76-9 |
Batch Quantity |
400kg |
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Batch No. |
MLP-PPH-20231114 |
Hnub tsim khoom |
2025.11.14 |
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Tshaj Tawm Hnub |
2025.11.17 |
Hnub tim rov kuaj dua |
2027.11.13 |
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Cov khoom kuaj |
Specifications | Cov qhabnias xeem | |
|
PEB 2010 /EP6 |
Qhov tshwm sim |
crystalline hmoov |
Ua raws |
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Melting point |
Txog 205 degree |
206.4℃~ 206.7 degree |
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Kev txheeb xyuas |
Ua tau raws li qhov yuav tsum tau ua |
Ua raws |
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Qhov tshwm sim ntawm daws |
Ntshiab, tsis khaus ntau dua Y7 |
Ua raws |
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PH |
2.4~3.0 |
2.60 |
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Poob rau ziab |
Tsawg dua los yog sib npaug li 0.5% |
0.04% |
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Sulfated tshauv |
Tsawg dua lossis sib npaug li 0.1% |
0.01% |
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Cov hlau hnyav |
Tsawg dua lossis sib npaug li 20 ppm |
<20 ppm |
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Cov khoom muaj feem xyuam |
Tsawg dua lossis sib npaug li 0.25% |
Ua raws |
|
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Assay |
99.0%~101.0% |
99.8% |
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USP32 |
Kev txheeb xyuas |
Ua tau raws li qhov yuav tsum tau ua |
Ua raws |
|
Poob rau ziab |
Tsawg dua los yog sib npaug li 0.5% |
0.04% |
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Residue ntawm ignition |
Tsawg dua lossis sib npaug li 0.1% |
0.01% |
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Cov hlau hnyav |
Tsawg dua lossis sib npaug li 0.003% |
<0.003% |
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Residue kuab tshuaj - Ethanol |
Tsawg dua los yog sib npaug li 0.5% |
<0.04% |
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Chloride |
16.9%~17.6% |
17.1% |
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|
Assay |
98.0%~102.0% |
100.0% |
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Xaus: Cov khoom ua tau raws li BP2010 / USP32 / EP6 tus qauv |
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Main Functions & Pharmacological Effects
Inhibits hormonal secretionNws inhibits kev tso tawm ntau yam kab mob hauv plab thiab pituitary cov tshuaj hormones, suav nrog kev loj hlob hormone, glucagon, insulin, gastrin thiab vasoactive plab hnyuv peptide (VIP).
Txo cov ntshav visceralNws txo qis splanchnic ntshav khiav thiab portal venous siab.
Txo cov tsos mob ntsig txog kev kho mobNws alleviates mob raws plab, yaug thiab mob plab tshwm sim los ntawm ntau ntau cov tshuaj hormones secretion.
Daim ntawv thov ntawmOctreotide Acetate
AcromegalyKho acromegaly tshwm sim los ntawm kev loj hlob ntawm cov tshuaj hormone secretion, txo cov tsos mob thiab txo qis cov tshuaj hormones.
Neuroendocrine qogTswj cov tsos mob ntawm cov qog carcinoid, VIPomas, glucagonomas thiab insulinomas.
Upper gastrointestinal los ntshavSiv rau kev tswj kev kub ntxhov ntawm cov ntshav los ntawm txoj hlab pas thiab gastric varices.
Mob hnyav refractory raws plabRelieves intractable raws plab txuam nrog ntau yam mob.
Cov kab mob pancreaticPab kho tus mob pancreatitis thiab tiv thaiv cov teeb meem tom qab phais mob pancreatic.
Kev noj tshuaj Octreotide Acetate
Standard niaj hnub regimen: 20 mcg txhaj subcutaneously ib hnub ib zaug, nyiam dua thaum sawv ntxov. Tig qhov chaw txhaj tshuaj (thigh, plab, lossis sab caj npab) kom tsis txhob muaj tawv nqaij.
Lwm txoj kev tswj hwm: Cov kev tshawb fawb soj ntsuam tau tshawb xyuas ob zaug-lub lim tiam kev tswj hwm (piv txwv li, 80 mcg ib koob) raws li kev xaiv zoo nrog cov txiaj ntsig zoo ntawm cov pob txha pob txha pob txha, txawm tias qhov no tsis pom zoo thoob ntiaj teb.
Kev kho mob ntev: Qhov siab tshaj plaws tau pom zoo rau kev kho mob tas mus li yog 24 lub hlis vim muaj peev xwm xav txog kev nyab xeeb mus sij hawm ntev.
Cov kev ceev faj
Cov Lus Qhia
Kev txhaj tshuaj subcutaneous: Tig qhov chaw txhaj tshuaj (lub plab, ncej puab, sab caj npab) kom tsis txhob muaj qhov khaus hauv zos. Txhaj tsawg kawg yog 1 nti ntawm qhov chaw dhau los.
LAR kev npaj: Yuav tsum tau tswj hwm los ntawm tus kws kho mob uas siv cov khoom siv. Tsis txhob co lub vial; maj mam swirl mus sib tov.
Ceeb toom kev nyab xeeb
Cov teeb meem gallbladder: Kev siv mus sij hawm ntev yuav ua rau muaj kab mob gallstones lossis biliary sludge. Saib xyuas cov tsos mob xws li mob plab sab xis lossis jaundice.
Ntshav qab zib hloov: tuaj yeem ua rau mob ntshav qab zib mellitus lossis hyperglycemia, tshwj xeeb tshaj yog rau cov neeg mob ntshav qab zib. Saib xyuas cov ntshav qabzib tsis tu ncua, kho cov tshuaj tiv thaiv kab mob raws li xav tau.
Cov thyroid ua haujlwm: Tsis tshua muaj mob ntawm hypothyroidism tau tshaj tawm nrog cov qauv ua haujlwm ntev. Xav txog kev kuaj cov thyroid ua haujlwm raws sijhawm.
Cov tshuaj sib cuam tshuam
Cyclosporine: Tej zaum yuav txo cov qib cyclosporine; saib xyuas cov ntshav kom zoo.
Cov tshuaj insulin / qhov ncauj hypoglycemic: Ua kom muaj kev pheej hmoo hypoglycemic; kho cov koob tshuaj raws li kev saib xyuas kho mob.
Beta-blockers: Tej zaum yuav npog cov tsos mob ntawm hypoglycemia (xws li, tachycardia).
Cov Lus Qhia Cia
Txhaj tshuaj: Khaws cov vials uas tsis tau qhib ntawm 2℃txog 8℃(36℃F txog 46℃F). Thaum qhib, tso rau hauv tub yees thiab siv tsis pub dhau 14 hnub.
LAR hmoov: Khaws ntawm chav sov (15℃txog 30℃/ 59℃F txog 86℃F). Reconstituted daws yuav tsum tau siv tam sim ntawd.
Kev tswj hwm ntawm Octreotide Acetate
Octreotide acetate muaj ob lub ntsiab formulations nrog ntau txoj kev tswj hwm thiab lub sijhawm:
1. Tam sim ntawd tso tawm octreotide acetate
Txoj kev: Kev txhaj tshuaj subcutaneous (feem ntau) lossis txhaj tshuaj rau hauv cov hlab ntsha.
Kev siv: Muab ntau zaus txhua hnub raws li kev kho mob xav tau. Kev tswj hwm IV feem ntau yog rau cov xwm txheej kub ntxhov xws li los ntshav variceal.
2. Long-acting depot formulation
Txoj kev: Sib sib zog nqus intramuscular txhaj rau hauv cov leeg gluteal.
Kev siv: Txhaj tshuaj ib zaug txhua 4 lub lis piam rau kev kho mob mus sij hawm ntev.
Octreotide Acetate vs. Comparable Drugs
1. Versus Ntuj Somatostatin
Ib nrab-life & dosing: Somatostatin muaj ib nrab-lub neej luv luv (1-3 feeb), xav taunruam IV infusion. Octreotide muaj ib nrab-lub neej ntev, muab los ntawm kev txhaj tshuaj sib nrug.
Kev xaiv: Octreotide nyiam txwv kev loj hlob hormone, glucagon thiab VIP. Somatostatin inhibits ze li ntawm tag nrho cov plab hnyuv siab raum, pancreatic thiab pituitary cov tshuaj hormones tsis xaiv.
Kev siv tshuaj kho mob: Somatostatin tsuas yog siv rau kev kho mob xwm txheej ceev. Octreotide haum rau ob qho tib si kev saib xyuas mob thiab kev tswj xyuas ntev ntev.
2. Rau Acromegaly
(1) Dopamine agonists (Bromocriptine, Cabergoline)
Kev ua tau zoo: Dopamine agonists ua haujlwm tau zoo tsuas yog rau me me acromegaly. Octreotide tswj cov tshuaj hormones thiab cov tsos mob zoo dua nyob rau hauv nruab nrab thiab hnyav.
Cov nyhuv qog: Octreotide tuaj yeem txo qis qee cov qog pituitary; dopamine agonists tsis tshua txo cov qog loj.
Kev mob tshwm sim: Dopamine agonists tuaj yeem ua rau kiv taub hau, qaug zog thiab cov tsos mob puas hlwb. Octreotide feem ntau ua rau mob GI siab.
(2) Kev loj hlob hormone receptor antagonist (Pegvisomant)
Mechanism: Octreotide txo GH secretion; pegvisomant blocks GH receptors ncaj qha.
Cov qog nqaij hlav: Pegvisomant tsis txo cov qog, thaum octreotide tuaj yeem txo cov qog nqaij hlav.
Kev Siv: Lawv feem ntau ua ke rau kev kho mob acromegaly nyuaj.
3. Rau Carcinoid Syndrome & Neuroendocrine hlav
(1) Cov tshuaj tiv thaiv kab mob / tshuaj tiv thaiv kab mob
Cov tshuaj tiv thaiv kab mob tsis tu ncua tsuas yog yooj yim cov tsos mob ib ntus. Octreotide ua rau lub hauv paus ua rau los ntawm inhibiting qhov txawv txav ntawm cov tshuaj hormones tso tawm, xa cov kev pab ntev mus rau raws plab thiab dej ntws.
Kev txwv: Cov tsos mob feem ntau tsis ua rau mob hnyav carcinoid; octreotide yog thawj qhov kev xaiv.
(2) Tshuaj kho mob & tsom tshuaj tiv thaiv kab mob
Cov tshuaj tua kab mob tua cov qog nqaij hlav tab sis ua rau mob hnyav heev. Octreotide tsis rhuav tshem cov qog, tab sis tswj cov tsos mob thiab ua rau cov qog loj hlob qeeb nrog cov kev mob me me.
Txoj hauj lwm: Octreotide yog cov tshuaj tseem ceeb rau kev tswj cov tsos mob palliative.
4. Rau Esophageal Variceal los ntshav
Kev sib piv nrog Vasopressin / Terlipressin
Kev Ua: Ob leeg txo qhov siab ntawm lub portal kom tsis txhob los ntshav.
Kev Nyab Xeeb: Vasopressin ua rau vasoconstriction thoob plaws, ua rau muaj kev pheej hmoo ntawm myocardial ischemia thiab mob ceg. Octreotide ua rau kev xaiv ntawm cov hlab ntsha visceral nrog tsawg dua cov kab mob plawv tsis zoo.
Kev nyiam kho mob: Octreotide yog tam sim no tus neeg sawv cev nyiam rau kev los ntshav variceal.
5. Zuag qhia tag nrho Pros thiab Cons ntawm Octreotide Acetate
Qhov zoo
Ntev ntev thiab siab dua cov tshuaj hormone inhibition xaiv ntau dua li ntuj somatostatin.
Dual formulations (short-acting / long-acting depot) haum thaum muaj xwm ceev thiab kev kho mob ntev.
Superior kev nyab xeeb profile piv nrog vasopressin thiab chemotherapy.
Qhov tsis zoo
Kev tswj xyuas tsuas yog los ntawm kev txhaj tshuaj; tsis muaj daim ntawv hais lus.
Kev siv mus ntev ua rau muaj kev pheej hmoo ntawm gallstones thiab mob plab hnyuv me.
Tus nqi siab dua li cov tshuaj kho mob ib txwm muaj.
Yuav ua li cas Octreotide Acetate ua haujlwm
Inhibit ntau dhau lawm cov tshuaj hormonesNws khi rau somatostatin receptors thoob plaws lub caj pas pituitary, pancreas thiab plab hnyuv ib ntsuj av. Nws muaj zog inhibits kev tso tawm ntau cov tshuaj hormones, suav nrog kev loj hlob hormone, glucagon, insulin, gastrin thiab vasoactive plab hnyuv peptide (VIP). Qhov no relieves cov tsos mob tshwm sim los ntawm cov tshuaj hormone overproduction.
Txo splanchnic ntshav txaus thiab portal siabNws constricts visceral hlab ntsha nyob rau hauv lub plab kab noj hniav, txo cov ntshav khiav mus rau lub digestive kabmob thiab txo portal venous siab. Cov nyhuv no yog qhov tseem ceeb rau kev tso ntshav los ntawm txoj hlab pas thiab plab varices.
Ua rau qeeb plab hnyuv motility thiab secretionNws slows lub zog ntawm txoj hnyuv thiab txo cov kua dej ntau dhau ntawm cov hnyuv. Nws ua tau zoo txo qhov mob raws plab uas cuam tshuam nrog cov qog neuroendocrine thiab lwm yam kab mob hauv plab hnyuv refractory.
Inhibit qog loj hlob (cov nyhuv nyob ib sab)Rau cov qog nqaij hlav neuroendocrine, nws tsis tsuas yog tswj hwm cov tsos mob ntsig txog cov tshuaj hormones tab sis tseem ua rau cov qog cell proliferation thiab kev loj hlob los ntawm kev ua ntawm qog somatostatin receptors.
Lwm yam Nootropics Raw Material kuj muaj
| Tianeptine sodium ntsev | 99% | 30123-17-2 |
| Tianeptine Acid | 99% | 66981-73-5 |
| Noopept | 99% | 157115-85-0 |
| Alpha-gpc | 99%/50% | 28319-77-9 |
| 5-HTP | 99% | 56-69-9 |
| CDP-Choline | 99% | 987-78-0 |
| Oxiracetam | 99% | 62613-82-5 |
| NSI-189 | 99% | 1270138-40-3 |
| Sunifiram | 99% | 314728-85-3 |
| Unifiram | 99% | 272786-64-8 |
| Pramiracetam | 99% | 68479-62-1 |
| Piracetam | 99% | 7491-74-9 |
| Agomelatin | 99% | 138112-76-2 |
Ntim & Shipping
Lub sij hawm xa tuaj:Nyob ib ncig ntawm 3-5 hnub ua haujlwm tom qab koj them nyiaj.
Pob: 1kg / aluminium ntawv ci hnab; 25Kgs hauv fiber ntau nruas nrog ob lub hnab yas sab hauv
Nthiab Nyhav:25kgs / Nruas / Gross Nyhav: 28kgs / Nruas
Drum Size & Volume:ID 42cm × H52cm, 0.08 m³ / Nruas
Cia:Khaws rau hauv qhov chaw qhuav thiab txias, kom deb ntawm lub teeb thiab cua sov.
Lub neej txee:Ob xyoos thaum khaws cia zoo.
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Pob |
1kg / hnab, 25kg / hnab; 25kg / nruas; customize raws li cov neeg siv khoom. |
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Kev thauj mus los |
Fedex, TNT, DHL, EMS, thiab lwm yam. |
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Chaw nres nkoj shipping |
Shanghai/Tianjin/Dalian/Beijing/Xi'an |
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Lub Sijhawm Lead |
1-2 hnub ua haujlwm tom qab tau txais cov nyiaj them poob haujlwm |
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Rau kev txiav txim loj, nws yuav xa los ntawm huab cua lossis hiav txwv. |
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FAQ
Q: 1. Kuv xav paub ntau ntxiv txog cov khoom, kuv tuaj yeem tiv tauj koj li cas?
A: Koj tuaj yeem xa email nug peb txhua lub sijhawm. Yog xav paub ntau ntxiv, kuv xav tau cov ntaub ntawv hauv qab no: cov khoom npe, xaj kom muaj nuj nqis, lub teb chaws tau txais, cov kev xav tau zoo, thiab lwm yam.
Q: 2. Kuv yuav paub li cas yog tias koj cov khoom muaj tseeb lossis cuav?
A: Peb yuav tshuaj xyuas txhua qhov khoom xa tuaj. Kuv tuaj yeem muab cov ntawv xeem suav nrog HPLC, MS thiab HNMR yog tias koj xav tau. Thov nrhiav tus kws tshaj lij kws tshuaj los pab koj paub meej tias qhov tseeb ntawm daim ntawv xeem.
Tau kawg, koj tuaj yeem yuav cov qauv coj los coj koj ncig koj qhov kev ntseeg siab.
Q: 3. Koj yuav ua li cas thiaj li muaj kev nyab xeeb ntawm pob khoom kuv tau txais?
A: Kuv xav tau lub pob kom zoo, Kuv yuav tsum xub paub koj qhov chaw nyob xa khoom, koj puas muaj txoj kev xa khoom xa tuaj, koj puas yuav los ntawm Tuam Tshoj?
Vim li cas koj thiaj xav paub?
Vim hais tias txhua lub teb chaws muaj cov kev cai sib txawv rau cov pob khoom txawv teb chaws, tshwj xeeb tshaj yog cov khoom siv tshuaj, koj yuav tsum paub cov ntaub ntawv yooj yim los muab kev xaiv zoo tshaj plaws rau koj.
Tam sim no, peb muaj cov kws tshaj lij kev lis kev cai hauv tebchaws EU, Tebchaws Meskas, Tebchaws Meskas, Canada, thiab Southeast Asia. Peb muaj cov kws tshaj lij kev lis kev cai tshem tawm cov neeg ua haujlwm kom ntseeg tau tias muaj kev nyab xeeb ntawm pob khoom.
Q: 4. Yuav them li cas?
A: Peb cov kev them nyiaj xws li bittoin, bank card, Western Union, Allegitudes, thiab lwm yam.
Nws yog feem ntau pom zoo tias cov neeg siv khoom them nrog Bitcoin, vim tias tus nqi qis, qhov nkag tau nrawm, thiab kev ruaj ntseg yog lav.
Q: 5. Nws yuav siv sij hawm ntev npaum li cas thiaj tau txais pob?
A: Qhov no yuav txawv raws li txoj kev xa khoom koj xaiv. Kuv yuav qhia luv luv txog peb cov kab tshwj xeeb uas nquag siv.
Feem ntau cov teb chaws Europe 10-15 hnub tom qab xa koj tus lej taug qab.
Hauv Tebchaws Meskas thiab Canada, feem ntau nws yuav siv sijhawm 7-10 hnub.
Cov teb chaws Esxias sab hnub tuaj yog 3-7 hnub.
Cim npe nrov: Tuam Tshoj octreotide acetate peptides manufacturers, lwm tus neeg, Hoobkas
