| Khoom npe | Plecanatide |
| Synonym | SP-304, Trulance nquag moiety, Uroguanylin analog |
| CAS Nr. | 467426‑54‑6 |
| Acetate ntsev CAS | 1075732‑84‑1 |
| Amino-acid Sequence | H-Asn-Asp-Glu-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH |
| Qhov tshwm sim | Dawb mus rau dawb amorphous hmoov |
| Molecular Formula | C65H104N18O26S4 |
| Molecular Luj | 1681.89 Da |
| Purity | Ntau dua lossis sib npaug li 98% HPLC |
| Solubility | Soluble nyob rau hauv dej & aqueous buffer; soluble hauv dilute acetic acid, DMSO; tsis txhob muaj zog alkaline mob |
| Pob | Txias-pack / ice-pack tsheb thauj mus los, yuav tsum muaj teeb pom kev zoo |
| Cia | Muab kaw, txias thiab qhuav qhov chaw, -20℃pom zoo rau kev khaws cia ntev |
| Txee-Lub neej | 24 Lub Hlis |
Khoom Description
Plcanatide yog dab tsi?
Plecanatide (CAS 467426-54-6, code SP-304), active moiety ntawm Trulance®, yog ib tug hluavtaws 16-amino-acid bicyclic peptide API thiab uroguanylin analog. Stabilized los ntawm ob daim ntawv cog lus intramolecular disulfide, nws ua raws li lub zog guanylate cyclase-C (GC-C) receptor agonist ua haujlwm hauv zos hauv lub plab zom mov nrog kev nqus tsawg kawg nkaus. Raws li kev ua kom receptor, nws nce qib cGMP intracellular los txhawb cov kua dej hauv plab thiab ua kom lub plab hla mus. Qhov no dawb-rau-tawm-dawb amorphous peptide hmoov yog dav siv rau kev tshawb fawb txog tshuaj digestive thiab kev tsim tshuaj. Nws yog npaj rau R & D thiab tsim cov hom phiaj nkaus xwb, tsis yog rau kev tswj hwm tib neeg.
Cov tshuaj muaj feem xyuam yog guanylate cyclase-C (GC-C) agonist peptides. Feem ntau ntawm lawv muaj cov qauv ntawm cov disulfide-bonded cyclic thiab ua nyob rau hauv lub zos nyob rau hauv lub plab hnyuv ib ntsuj av tau nrog tsawg tsawg systemic absorption. Lawv tau siv dav rau kev tshawb fawb ua ntej kev kho mob thiab kev tsim kho tshuaj tsim kho lub hom phiaj rau cem quav, IBS-C thiab kev tshawb fawb ntawm plab hnyuv mucosal homeostasis. Lawv txawv nyob rau hauv cov amino-acid sequence, disulfide-bond suav, pH-sensitivity thiab proteolytic stability rau txawv project.
| Khoom npe | CAS Nr. | Core Feature |
| Linaclotide | 851199‑59‑2 | 14-amino-acid peptide, peb daim ntawv cog lus disulfide, GC-C agonist |
| Dolcanatide | 2137114‑18‑8 | Uroguanylin analog, txhim kho protease kuj, ob disulfide bonds |
| Uroguanylin | 148352‑74‑3 | Endogenous tib neeg txoj hnyuv peptide ligand rau GC-C receptor |
| Guanylin | 140667‑14‑1 | Endogenous plab hnyuv peptide, haiv neeg GC-C agonist |
Kev siv ntawm Plcanatide
Plecanatide yog ib qho hluavtaws bicyclic peptide npaj rau kev siv tshuaj R & D thiab kev tsim kho ua ntej. Raws li ib tug guanylate cyclase-C (GC-C) receptor agonist, nws tsuas yog ua rau lub plab hnyuv mucosal receptors los txhawb txoj hnyuv tso kua mis thiab ua kom lub plab hnyuv. Nws yog dav siv nyob rau hauv kev tshawb fawb tshuaj rau constipation ntev thiab chim siab plob tsis so tswj syndrome nrog cem quav (IBS-C). Cov lus qhia kev txhim kho feem ntau suav nrog kev tshuaj ntsuam xyuas qhov ncauj peptide, kev ntsuas kev ruaj ntseg ntawm disulfide-bonded peptides, in-vitro cell-based receptor act assays, thiab pre-clinical animal model study. Vim nws cov cuab yeej nqus dej tsawg, nws kuj tseem siv rau kev tshawb fawb ntawm plab hnyuv mucosal physiology. Cov khoom siv peptide no tsuas yog siv rau kev kuaj thiab tsim kho lub hom phiaj nkaus xwb, tsis yog siv rau tib neeg kev kho mob. Cov neeg siv khoom yuav tsum ua kom tiav tag nrho cov kev ntsuam xyuas ua ntej kev lag luam tawm tshuaj.
Cov txiaj ntsig ntawm Plcanatide
Targeted GI Action: Ua tshwj xeeb rau hauv plab hnyuv GC-C receptors nrog kev nqus tsawg tsawg, txo qis cov kev mob tshwm sim thiab txhim kho cov tshuaj tiv thaiv kev nyab xeeb.
1.Stable Structural Activity: Dual intramolecular disulfide daim ntawv cog lus kom ruaj khov molecular conformation thiab sustained lom lom.
High Purity & Consistency: Ntau dua los yog sib npaug rau 98% HPLC purity, nruj impurity tswj, ruaj khov batch zoo rau kws tshuaj-qib R & D thiab kev tshawb fawb ua ntej
2.Professional Pharmacological Properties: Ua tau zoo txhawb txoj hnyuv tso kua mis thiab ua kom lub plab hla mus, zoo tagnrho rau cem quav thiab IBS-C tshuaj txhim kho
3.Excellent Formulation Adaptability: Zoo dej solubility thiab nruab nrab protease stability, haum rau qhov ncauj peptide formulation tshuaj ntsuam xyuas thiab txheej txheem optimization
4.Ua tiav cov ntaub ntawv txhawb nqa: Nruab nrog LC-MS, HPLC, COA, SDS thiab TDS, txhawb kev tshawb fawb kev kawm, kev sau npe ua haujlwm thiab cov ntaub ntawv tshuaj.
5.Wide Application Flexibility: Muaj feem xyuam rau kev soj ntsuam kev ua haujlwm ntawm tes, kev sim tsiaj ua qauv thiab kev tsim kho tshuaj ua ntej
Packing & Shipping
1.Professional Peptide Ntim: Nqus-sealed sterile vial ntim, tiv thaiv oxidation, noo noo-pov thawj thiab lub teeb-shielding, zoo tiv thaiv disulfide daim ntawv cog lus thiab kev ua haujlwm lom.
2.Diversified Specification Options: Micro sample ntim (5mg / 10mg / 50mg / 100mg) rau kev kuaj sim; customized me me batch ntim rau kev kuaj ua ntej
3.Strict Cold-Chain Logistics: Kev thauj mus los tsis tshua muaj kub nrog cov pob khov nab kuab / xiav dej khov, tswj qhov kub thiab txias, tsis txhob kub siab thiab rov ua kom khov-thawing puas
4.Export-Qib Kev Nyab Xeeb Kev Tiv Thaiv: Shockproof thiab siab-resistant txheej ntim, haum rau kev mus ncig thoob ntiaj teb huab cua thiab hiav txwv.
5.Complete Supporting Documents: Nruab nrog COA, SDS, HPLC thiab LC-MS cov ntaub ntawv, txhawb kev lis kev cai clearance thiab kev tshawb fawb tshuaj
Hu rau PAGE
Yog tias koj tab tom nrhiav Plecanatide peptide raw cov ntaub ntawv rau kev tshawb fawb ntawm plab hnyuv, peb txhawb nqa kev soj ntsuam kuaj thiab kev txiav txim rau kev tsav tsheb. Lub tshuab nqus tsev los tiv thaiv oxidation ntim thiab kev ua haujlwm txias-chain xa khoom tau txais yuav los tswj peptide stability. Xa koj qhov kev nug rau cov ntaub ntawv hauv qab no.
1.Nrhiav txoj kev:
Email: alice@xaheshun.com
whatspp: +8618509260106
Online instant messaging
2. Hu rau cov ntaub ntawv:
Lub npe: Alice
Xov tooj: +8618509260106
Email: alice@xaheshun.com
FAQ
Q: Tus lej CAS ntawm Plcanatide yog dab tsi?
A: Plcanatide CAS naj npawb yog467426‑54‑6. Nws daim ntawv acetate ntsev muaj cais CAS: 1075732-84-1. Nws tseem hu ua SP-304 hauv kev tshawb fawb peptide.
Q: Dab tsi yog qhov purity ntawm koj Plecanatide peptide?
A: Peb Plecanatide ntau dua los yog sib npaug rau 98% purity kuaj los ntawm RP-HPLC. Cov qib impurity yog nruj me ntsis tswj kom tau raws li kev tshawb fawb tshuaj.
Q: Dab tsi yog qhov sib lawv liag thiab cov yam ntxwv ntawm Plecanatide?
A: Plecanatide yog 16-amino-acid peptide uas muaj ob daim ntawv cog lus intramolecular disulfide. Cov kev sib txuas ntawm cov disulfide yog qhov tseem ceeb los khaws nws cov kev ua haujlwm lom neeg.
Q: Kuv yuav khaws Plecanatide hmoov li cas?
A: Khaws cov hmoov nplej kom nruj rau ntawm-20 degree, tiv thaiv los ntawm lub teeb thiab noo noo. Tsis txhob hnov qab txog qhov kub thiab txias. Txee lub neej yog 24 lub hlis raws li kev pom zoo qub kaw cia. Thaum yaj, aliquot thiab khaws cia ntawm -80 degree.
Q: Cov kuab tshuaj dab tsi tuaj yeem yaj Plecanatide?
A: Plecanatide yog soluble hauv dej thiab aqueous tsis, kuj soluble hauv dilute acetic acid thiab DMSO. Muaj zog alkaline tej yam kev mob yuav tsum tau zam.
Cim npe nrov: Tuam Tshoj siab purity plecanatide peptide manufacturers, lwm tus neeg, Hoobkas
